Devotees of the Black Nazarene flock Quiapo Church to participate in the Holy Masses any day of the week but most especially on Friday. Friday is the regular day of devotion to the Sacred Heart of Jesus. Those who pray the rosary and the novena typically stay for a few minutes after the Holy Mass. Novenas are composed of prayers for nine consecutive days. They are prayed for the adoration of the Black Nazarene and the Blessed Virgin Mary. They are also meant to implore the intercession of Mother Mary and the saints. Devotees of the Black Nazarene hold a prayer booklet that contains Panalangin sa Nobena sa Mahal na Poong Hesus Nazareno ng Quiapo. They recite the prayers as a congregation during a novena mass. They pray the novena every Friday and for nine consecutive days prior to the procession of the Black Nazarene.

          The faithful typically pray for the intercession of saints in conveying their prayers to God. They appeal to specific saints on account of the blessings to be obtained from God through their intervention. Invoking the saints is usually done through novenas prayed or recited in front of their images presented in the church. Some passersby who do not intend to attend the Holy Mass linger for a few minutes to say their prayers.

          People who pray in the Quiapo Church come from different places of origin. They represent all levels of society and yet, they find a common ground where they exist in communal harmony and where they are one with God. Their union with God is achieved through fervent prayers that they perform in the loving home of the Black Nazarene. Devotees engrossed in deep prayer and contemplation are usually found seated in any of the long benches in the church that are systematically arranged to accommodate a huge congregation. Some of them say personal prayers while others pray the rosary or the novena.

          Manila Times (January, 2015) sums up the most significant effect of prayer and devotion to the Black Nazarene: “...the greatest miracle of all, which even believers take for granted, is the change in the attitude to God and religion, and the conversion from a life of vice to a life of virtue and tendernes.”